Publications

On this page, you can browse a selection of research studies and articles published
by the laboratory team over the year.

Publications Past 5 Years, For additional publications →

The landscape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential.

Sibony-Benyamini H, Jbara R, Shubash Napso T, Abu-Rahmoun L, Vizenblit D, Easton-Mor M, Perez S, Brandis A, Leshem T, Peretz A, Maman Y. Genome Med. 2025 Feb 24;17(1):14. doi: 10.1186/s13073-025-01439-3.PMID: 39994739.

Associations between biofilm formation and virulence factors among clinical Helicobacter pylori isolates.

Ashkar Daw M, Azrad M, Peretz A. Microb Pathog. 2024 Nov;196:106977. doi: 10.1016/j.micpath.2024.106977. Epub 2024 Sep 23.PMID: 39321970

Virulence factors, antibiotic susceptibility and sequence type distribution of hospital-associated Clostridioides difficile isolates in Israel, 2020-2022.

Schwartz O, Rohana H, Azrad M, Shor A, Rainy N, Maor Y, Nesher L, Sagi O, Peretz A. Sci Rep. 2024 Sep 4;14(1):20607. doi: 10.1038/s41598-024-71492-2.PMID: 39232075

Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity.

Safra M, Tamari Z, Polak P, Shiber S, Matan M, Karameh H, Helviz Y, Levy-Barda A, Yahalom V, Peretz A, Ben-Chetrit E, Brenner B, Tuller T, Gal-Tanamy M, Yaari G. Front Immunol. 2023 Apr 19;14:1031914. doi: 10.3389/fimmu.2023.1031914. eCollection 2023.PMID: 37153628

The epidemiology of intestinal protozoa in the Israeli population based on molecular stool test: a nationwide study.

Peretz A, Azrad M, Ken-Dror S, Strauss M, Sagas D, Parizada M, Loewnthal S, Amichay D, Ben Horin N, Shenhar Y, Sagi O, Bazarsky E, Amit S, Schwartz E. Microbiol Spectr. 2024 Aug 6;12(8):e0061624. doi: 10.1128/spectrum.00616-24. Epub 2024 Jul 16.PMID: 39012121

EFLM Task Force Preparation of Labs for Emergencies (TF-PLE) recommendations for reinforcing cyber-security and managing cyber-attacks in medical laboratories.

Lippi G, Akhvlediani S, Cadamuro J, Danese E, García de Guadiana Romualdo L, Delacour H, Favaloro EJ, Favresse J, Henry BM, Jovicic S, Kütt M, Moreno Y Banuls L, Ozben T, Peretz A, Perovic A, Thachil J, Yucel D, Plebani M. Clin Chem Lab Med. 2024 Jul 17;63(1):27-34. doi: 10.1515/cclm-2024-0803. Print 2025 Jan 29.PMID: 39008654

Mother-to-Neonate Transmission of Antibiotic-Resistant Bacteria: A Cross-Sectional Study.

Matok LA, Azrad M, Leshem T, Abuzahya A, Khamaisi T, Smolkin T, Peretz A. Microorganisms. 2021 Jun 8;9(6):1245. doi: 10.3390/microorganisms9061245.PMID: 34201210

Characterization of community-acquired Clostridioides difficile strains in Israel, 2020-2022.

Schwartz O, Rohana H, Azrad M, Shor A, Rainy N, Maor Y, Nesher L, Sagi O, Ken-Dror S, Kechker P, Peretz A. Front Microbiol. 2023 Dec 19;14:1323257. doi: 10.3389/fmicb.2023.1323257. eCollection 2023.PMID: 38169783

A Multi-Laboratory Evaluation of Commercial Monkeypox Virus Molecular Tests.

Erster O, Levy I, Kabat A, Mannasse B, Levy V, Assraf H, Azar R, Ben-Zvi H, Bradenstein R, Bunder O, Fadeela A, Keren-Naus A, Peretz A, Roif-Kaminsky D, Saleh L, Schreiber L, Schwartz O, Shaked-Mishan P, Sorek N, Strauss M, Steinberg R, Treygerman O, Zisman-Rozen S, Yishai R, Tejman-Yarden N, Mendelson E, Sofer D. Microbiol Spectr. 2023 Jun 15;11(3):e0022523. doi: 10.1128/spectrum.00225-23. Epub 2023 May 4.PMID: 37140382 

Characterization of reduced susceptibility to chlorhexidine among Gram-negative bacteria.

Leshem T, Gilron S, Azrad M, Peretz A. Microbes Infect. 2022 Mar;24(2):104891. doi: 10.1016/j.micinf.2021.104891. Epub 2021 Oct 8.PMID: 34628010

In vitro susceptibility of clinical Clostridioides difficile isolates in Israel to metronidazole, vancomycin, fidaxomicin, ridinilazole and ibezapolstat.

Schwartz O, Azrad M, Peretz A. BMC Gastroenterol. 2025 Mar 31;25(1):209. doi: 10.1186/s12876-025-03800-7.PMID: 40165093

Rapid SARS-CoV-2 Detection Using the Lucira™ Check It COVID-19 Test Kit.

Zahavi M, Rohana H, Azrad M, Shinberg B, Peretz A. Diagnostics (Basel). 2022 Aug 3;12(8):1877. doi: 10.3390/diagnostics12081877.PMID: 36010227

Should pregnant women be screened for SARS-CoV-2 infection? A prospective multicenter cohort study.

Yefet E, Massalha M, Alter A, Gal Harnik A, Hosari Mahamed S, Novick L, Wattad M, Sakas J, Baram S, Weiss A, Iskander R, Peretz A, Rozenberg O, Younis JS, Perlitz Y, Nachum Z . Int J Gynaecol Obstet. 2023 Jan;160(1):161-166.

High throughput optical modulation biosensing for highly sensitive and rapid detection of biomarkers.

Burg S, Roth S, Cohen M, Avivi-Mintz S, Margulis M, Rohana H, Peretz A, Danielli A. Talanta. 2022 Oct 1;248:123624. doi: 10.1016/j.talanta.2022.123624. Epub 2022 Jun 1.PMID: 3566099

Trend of Changes in Chloramphenicol Resistance during the Years 2017-2020: A Retrospective Report from Israel.

Rohana H, Hager-Cohen A, Azrad M, Peretz A. Antibiotics (Basel). 2023 Jan 18;12(2):196. doi: 10.3390/antibiotics12020196.PMID: 36830107

Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations.

Roshrosh H, Rohana H, Azrad M, Leshem T, Masaphy S, Peretz A. World J Gastroenterol. 2023 Jan 7;29(1):190-199. doi: 10.3748/wjg.v29.i1.190.PMID: 36683715

Sexually Transmitted Diseases in Northern Israel: Insights From a Large Referral Laboratory.

Kridin K, Ingram B, Becker D, Shiloah N, Azrad M, Habib S, Peretz A. J Low Genit Tract Dis. 2023 Jan 1;27(1):51-55. doi: 10.1097/LGT.0000000000000717. Epub 2022 Nov 30.PMID: 36449696

Impact of dental clearance on bacteremia in hematopoietic cell transplantation.

Zadik Y, Krasovsky A, Cohen R, Rettman A, Aframian DJ, Avni B, Peretz A, Keshet N. Oral Dis. 2024 Sep;30(6):4011-4013. doi: 10.1111/odi.14911. Epub 2024 Feb 29.PMID: 38424723 No abstract available.

Antibiotic Resistance and Biofilm Production Capacity in Clostridioides difficile.

Rahmoun LA, Azrad M, Peretz A. Front Cell Infect Microbiol. 2021 Aug 4;11:683464. doi: 10.3389/fcimb.2021.683464. eCollection 2021.PMID: 34422678 

The Impact of a Positive Biofire® FilmArray® Gastrointestinal Panel Result on Clinical Management and Outcomes.

Carmon D, Rohana H, Azrad M, Peretz A. Diagnostics (Basel). 2023 Mar 14;13(6):1094. doi: 10.3390/diagnostics13061094.PMID: 36980402

Nucleic acid hybridization-based detection of pathogenic RNA using microscale thermophoresis.

Avivi MY, Touitou N, Rohana H, Lerrer B, Shav-Tal Y, Peretz A, Cohen HY. J Biol Chem. 2024 Mar;300(3):105676. doi: 10.1016/j.jbc.2024.105676. Epub 2024 Jan 24.PMID: 38278326

Antibiotic resistance patterns of Helicobacter pylori in North Israel - A six-year study.

Azrad M, Vazana D, On A, Paritski M, Rohana H, Roshrosh H, Agay-Shay K, Peretz A. Helicobacter. 2022 Dec;27(6):e12932. doi: 10.1111/hel.12932. Epub 2022 Sep 15.PMID: 36110057

The effect of different C. difficile MLST strains on viability and activity of macrophages.

Saad G, Azrad M, Aias M, Leshem T, Hamo Z, Rahmoun LA, Peretz A. Heliyon. 2023 Feb 17;9(3):e13846. doi: 10.1016/j.heliyon.2023.e13846. eCollection 2023 Mar.PMID: 36873553

Comparison of FT-IR with whole-genome sequencing for identification of maternal-to-neonate transmission of antibiotic-resistant bacteria.

Azrad M, Matok LA, Leshem T, Peretz A. J Microbiol Methods. 2022 Nov;202:106603. doi: 10.1016/j.mimet.2022.106603. Epub 2022 Oct 23.PMID: 36283506

The microbial diversity following antibiotic treatment of Clostridioides difficile infection.

Binyamin D, Nitzan O, Azrad M, Hamo Z, Koren O, Peretz A. BMC Gastroenterol. 2021 Apr 13;21(1):166. doi: 10.1186/s12876-021-01754-0.PMID: 33849457

Assessing the impact of a positive Biofire® FilmArray® Meningitis/Encephalitis Panel result on clinical management and outcomes.

Dahan Nassy S, Azrad M, Abozaid S, Glikman D, Zayyad H, Zaidman-Shimshovitz A, Peretz A. Diagn Microbiol Infect Dis. 2022 Nov;104(3):115769. doi: 10.1016/j.diagmicrobio.2022.115769. Epub 2022 Jul 18.PMID: 35964557

Incidence of biofilm formation among MRSA and MSSA clinical isolates from hospitalized patients in Israel.

Leshem T, Schnall BS, Azrad M, Baum M, Rokney A, Peretz A. J Appl Microbiol. 2022 Aug;133(2):922-929. doi: 10.1111/jam.15612. Epub 2022 May 16.PMID: 35503533

Unmasking Myocardial Dysfunction in Patients Hospitalized for Community-Acquired Pneumonia Using a 4-Chamber 3-Dimensional Volume/Strain Analysis.

Khatib M, Elbaz-Greener G, Nitzan O, Soboh S, Peretz A, Hazanov E, Kinany W, Halahla Y, Grosman-Rimon L, Houle H, Amir O, Carasso S. J Digit Imaging. 2022 Dec;35(6):1654-1661. doi: 10.1007/s10278-022-00665-0. Epub 2022 Jun 15.PMID:

Dynamics of Invasive Pneumococcal Disease in Israel in Children and Adults in the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Era: A Nationwide Prospective Surveillance.

Ben-Shimol S, Regev-Yochay G, Givon-Lavi N, van der Beek BA, Brosh-Nissimov T, Peretz A, Megged O, Dagan R; Israeli Pediatric Bacteremia and Meningitis Group (IPBMG); Israeli Adult Invasive Pneumococcal Disease (IAIPD) Group. Clin Infect Dis. 2022 May 3;74(9):1639-1649. doi: 10.1093/cid/ciab645.PMID: 34293091

Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile.

Azrad M, Abu-Rahmoun L, Hamo Z, Peretz A. Microb Pathog. 2024 Jan;186:106490. doi: 10.1016/j.micpath.2023.106490. Epub 2023 Dec 5.PMID: 38061667

Unraveling antimicrobial resistance in Helicobacter pylori: Global resistome meets global phylogeny.

Domanovich-Asor T, Craddock HA, Motro Y, Khalfin B, Peretz A, Moran-Gilad J. Helicobacter. 2021 Apr;26(2):e12782. doi: 10.1111/hel.12782. Epub 2021 Jan 25.PMID: 33491828

IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of C. difficile Infection.

Gotshal D, Azrad M, Hamo Z, Nitzan O, Peretz A. Pathogens. 2021 May 20;10(5):631. doi: 10.3390/pathogens10050631.PMID: 34065379

Biofilm Formation by Hospital-Acquired Resistant Bacteria Isolated from Respiratory Samples.

Ben-Amram H, Azrad M, Cohen-Assodi J, Sharabi-Nov A, Edelstein S, Agay-Shay K, Peretz A. J Epidemiol Glob Health. 2024 Jun;14(2):291-297. doi: 10.1007/s44197-024-00215-7. Epub 2024 Apr 2.PMID: 38564110

Tinea capitis in an immigrant pediatric community; a clinical signs-based treatment approach.

Kassem R, Shemesh Y, Nitzan O, Azrad M, Peretz A.BMC Pediatr. 2021 Aug 26;21(1):363. doi: 10.1186/s12887-021-02813-x.PMID: 34445992 

Mycoplasma genitalium 's Antibiotic Resistance in Sexually Transmitted Infections Clinics in Israel.

Azrad M, Saleh N, Zur IY, Becker D, Shiloah N, Habib S, Peretz A. J Low Genit Tract Dis. 2024 Oct 1;28(4):356-359. doi: 10.1097/LGT.0000000000000828. Epub 2024 Jul 9.PMID: 38980157

Genomic Analysis of Antimicrobial Resistance Genotype-to-Phenotype Agreement in Helicobacter pylori.

Domanovich-Asor T, Motro Y, Khalfin B, Craddock HA, Peretz A, Moran-Gilad J. Microorganisms. 2020 Dec 22;9(1):2. doi: 10.3390/microorganisms9010002.PMID: 33374988

Different bile acids have versatile effects on sporulation, toxin levels and biofilm formation of different Clostridioides difficile strains.

Aias M, Azrad M, Saad G, Leshem T, Hamo Z, Rahmoun LA, Peretz A. J Microbiol Methods. 2023 Mar;206:106692. doi: 10.1016/j.mimet.2023.106692. Epub 2023 Feb 20.PMID: 36809809 

Reduced Susceptibility to Chlorhexidine among Staphylococcus aureus Isolates in Israel: Phenotypic and Genotypic Tolerance.

Azrad M, Shmuel C, Leshem T, Hamo Z, Baum M, Rokney A, Agay-Shay K, Peretz A. Antibiotics (Basel). 2021 Mar 23;10(3):342. doi: 10.3390/antibiotics10030342.PMID: 33807049

Evaluation of the NG-Test CARBA 5 Kit for Rapid Detection of Carbapenemase Resistant Enterobacteriaceae.

Ben-Haim O, Azrad M, Saleh N, Tkhawkho L, Peretz A. Lab Med. 2021 Jul 1;52(4):375-380. doi: 10.1093/labmed/lmaa084.PMID: 33159512

A new antigen test device for rapid influenza A and B detection.

Rohana H, Marmur G, Azrad M, Peretz A. Heliyon. 2024 Jul 2;10(13):e33979. doi: 10.1016/j.heliyon.2024.e33979. eCollection 2024 Jul 15.PMID: 39055805

The diagnostic performance and accuracy of 3 molecular assays for the detection of Clostridium difficile in stool samples, compared with the Xpert® C. difficile assay.

Azrad M, Tkhawkho L, Hamo Z, Peretz A. J Microbiol Methods. 2020 Jan;168:105784. doi: 10.1016/j.mimet.2019.105784. Epub 2019 Nov 20.PMID: 31758952

Evaluation of Factors that Affect the Performance of COVID-19 Molecular Assays Including Presence of Symptoms, Number of Detected Genes and RNA Extraction Type.

Jerbi L, Azrad M, Peretz A. Mol Diagn Ther. 2022 Mar;26(2):229-238. doi: 10.1007/s40291-021-00574-y. Epub 2022 Jan 24.PMID: 35072934

blaGES-producing ST654 comprises a quarter of all carbapenem-resistant Pseudomonas aeruginosa in blood isolates from 15 hospitals.

Kon H, Lurie-Weinberger MN, Bechor M, Temkin E, Kastel O, Schwartz D, Keren-Paz A, Carmeli Y; CRPA Working Group. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0096524. doi: 10.1128/aac.00965-24. Epub 2024 Oct 31.PMID: 39480074 

Highly sensitive extraction-free saliva-based molecular assay for rapid diagnosis of SARS-CoV-2.

Margulis M, Rohana H, Erster O, Mandelboim M, Biber A, Schwartz E, Peretz A, Danielli A. J Clin Microbiol. 2024 Jun 12;62(6):e0060024. doi: 10.1128/jcm.00600-24. Epub 2024 May 24.PMID: 38785448

Diagnosing gastrointestinal infections based on cycle threshold cut-offs of PCR.

Karam R, Kechker P, Ken-Dror S, Peretz A, Azrad M. Microbiol Spectr. 2025 Feb 4;13(2):e0123424. doi: 10.1128/spectrum.01234-24. Epub 2024 Dec 19.PMID: 39699270

Association of Streptococcus bovis presence in colonic content with advanced colonic lesion.

Paritsky M, Pastukh N, Brodsky D, Isakovich N, Peretz A. World J Gastroenterol. 2015 May 14;21(18):5663-7. doi: 10.3748/wjg.v21.i18.5663.PMID: 25987793

Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel.

Miller D, Martin MA, Harel N, Tirosh O, Kustin T, Meir M, Sorek N, Gefen-Halevi S, Amit S, Vorontsov O, Shaag A, Wolf D, Peretz A, Shemer-Avni Y, Roif-Kaminsky D, Kopelman NM, Huppert A, Koelle K, Stern A. Nat Commun. 2020 Nov 2;11(1):5518. doi: 10.1038/s41467-020-19248-0.PMID: 33139704

Clinical isolate characteristics and demographics of patients with C.jejuni and C.coli infections in Northern Israel, 2015-2021.

Tsafrir O, Rohana H, Bousani L, Orsan K, Abozaid S, Azrad M, Peretz A. Epidemiol Infect. 2024 Feb 5;152:e19. doi: 10.1017/S0950268823002005.PMID: 38314639 

Mycoplasma and Ureaplasma carriage in pregnant women: the prevalence of transmission from mother to newborn.

Peretz A, Tameri O, Azrad M, Barak S, Perlitz Y, Dahoud WA, Ben-Ami M, Kushnir A. BMC Pregnancy Childbirth. 2020 Aug 11;20(1):456. doi: 10.1186/s12884-020-03147-9.PMID: 32781998

Characterization of Clostridioides difficile Strains, the Disease Severity, and the Microbial Changes They Induce.

Rohana H, Azrad M, Nitzan O, Adler A, Binyamin D, Koren O, Peretz A. J Clin Med. 2020 Dec 18;9(12):4099. doi: 10.3390/jcm9124099.PMID: 33353133

The Cytopathic Effect of Different Toxin Concentrations From Different Clostridioides difficile Sequence Types Strains in Vero Cells.

Hamo Z, Azrad M, Fichtman B, Peretz A. Front Microbiol. 2021 Oct 12;12:763129. doi: 10.3389/fmicb.2021.763129. eCollection 2021.PMID: 34712220

Serum Albumin to Creatinine Ratio as Predictor for 30-Day All-Cause Mortality in Patients with Clostridium difficile -Associated Diarrhea.

Nseir W, Njidat J, Amara A, Peretz A, Kahatib H, Mari A, Mahamid M, Farah R. Ann Clin Lab Sci. 2021 Jul;51(4):557-561.PMID: 34452896

Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overview.

Porat Ben Amy D, Rohana H, Azrad M, V Joachim M, Bar O, Abu El-Naaj I, Peretz A. Acta Odontol Scand. 2024 Sep 23;83:516-521. doi: 10.2340/aos.v83.41390.PMID: 39311869 

Detection of Carbapenem-Resistant Enterobacterales in Simulated Blood Culture in 15 Minutes.

Baer D, Azrad M, Saleh N, Peretz A. Life (Basel). 2021 Feb 14;11(2):145. doi: 10.3390/life11020145.PMID: 33672877

Publisher Correction: Virulence factors, antibiotic susceptibility and sequence type distribution of hospital-associated Clostridioides difficile isolates in Israel, 2020-2022.

Schwartz O, Rohana H, Azrad M, Shor A, Rainy N, Maor Y, Nesher L, Sagi O, Peretz A. Sci Rep. 2024 Sep 27;14(1):22042. doi: 10.1038/s41598-024-73686-0.PMID: 39333364

Clinical and Demographic Characteristics of Patients With a New Diagnosis of Carriage or Clinical Infection With Carbapenemase-Producing Enterobacterales: A Retrospective Study.

Adar A, Zayyad H, Azrad M, Libai K, Aharon I, Nitzan O, Peretz A. Front Public Health. 2021 Feb 5;9:616793. doi: 10.3389/fpubh.2021.616793. eCollection 2021.PMID: 33614584

Tumor necrosis factor inhibitors are associated with a decreased risk of COVID-19-associated hospitalization in patients with psoriasis-A population-based cohort study.

Kridin K, Schonmann Y, Damiani G, Peretz A, Onn E, Bitan DT, Cohen AD. Dermatol Ther. 2021 Jul;34(4):e15003. doi: 10.1111/dth.15003. Epub 2021 Jun 5.PMID: 34033207

Evaluation of vaccine perceptions in Israel's Elderly: A Comparative study of COVID-19 and influenza vaccination attitudes.

Abu Aid O, Rohana H, Azrad M, Peretz A. Vaccine X. 2024 Oct 2;20:100569. doi: 10.1016/j.jvacx.2024.100569. eCollection 2024 Oct.PMID: 39886533

The effect of three urease inhibitors on H. pylori viability, urease activity and urease gene expression.

Shaalan H, Azrad M, Peretz A. Front Microbiol. 2024 Nov 15;15:1464484. doi: 10.3389/fmicb.2024.1464484. eCollection 2024.PMID: 39619692  

Performance of the Influ a + B K-SeT® assay as compared to two RT-PCR assays for detection of influenza virus.

Peretz A, Zadok BS, Azrad M. Diagn Microbiol Infect Dis. 2020 Sep;98(1):115097. doi: 10.1016/j.diagmicrobio.2020.115097. Epub 2020 May 30.PMID: 32599417

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.

Graif N, Abozaid S, Peretz A. Microb Drug Resist. 2020 Nov;26(11):1342-1349. doi: 10.1089/mdr.2020.0111. Epub 2020 May 14.PMID: 32407193

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.

Hamo Z, Ninio H, Azrad M, Binyamin D, Zigdon M, Roshrosh H, Peretz A. Probiotics Antimicrob Proteins. 2025 Jun 18. doi: 10.1007/s12602-025-10586-3. Online ahead of print.PMID: 40531412

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.

Katz M, Azrad M, Glikman D, Peretz A. Vaccines (Basel). 2021 Dec 27;10(1):27. doi: 10.3390/vaccines10010027.PMID: 35062688